Objectives: Cardiovascular disease is the leading cause of death and a major source of workers’ compensation claims in Korea. Since 2000 the Korea Occupational Safety and Health Agency (KOSHA), working through local occupational health institutions, has supported cardiovascular disease prevention programs at a number of companies in Korea. The purpose of this study was to assess the short-term effects of this effort. Methods: A total of 11,077 workers at risk were enrolled in the workplace cardiovascular disease prevention program and 5,902 workers (53.3%) completed the 1-year course during 2007. The program consisted of a medical checkup and health counseling for the workers by occupational health nurses. The guidelines for this prevention program were adopted from KOSHA Code H-11-2004. To determine the program’s effectiveness, the workers’ risks for cardiovascular disease were assessed before and one year after completion of the program. Results: The intervention led to significant reductions in the mean systolic and diastolic blood pressures of 4.9 ㎜Hg and 3.1 ㎜Hg, respectively. Mean total cholesterol and BMI were also reduced significantly by 8.4 g/㎗ and 0.1 ㎏/㎡. The rate of smoking was decreased by 6.0% and the percentage of workers engaging in regular exercise was increased by 23.1%. Of the 3,530 workers with the low risk and above, the overall cardiovascular risk was improved in 1,734 (49.1%) of them. Conclusions: The cardiovascular disease prevention program supported by the Korea Occupational Safety and Health Agency reduces cardiovascular diseases risks among workers and may improve the health status of workers in Korea.