목적: 우리나라에서 납에 직업적으로 노출되지 않은 일부 중년 성인들의 골중납량과 혈중납량의 수준과 상호관련성을 알아보기 위하여 40세 이상 남자 86명 여자 51명 총 137명을 대상으로 본 연구를 시도하였다. 방법: 연구변수로 골중납량인 경골납량, 혈중납량을 택하였다. 경골납량은 K-shell XRF를 이용하여 각 대상자들을 30분간 측정하였고, 혈중납량은 원자흡광광도계법으로 분석하였다. 결과: 총대상자 137명의 경골납량의 평균±표준편차는 3.49±4.99 ㎍/g이었으며, 남자와 여자는 각각 3.90±4.88 ㎍/g 및 2.80±5.14 ㎍/g이었으나 양군 평균의 통계적 차이는 없었다. 한편 총대상자 137명의 혈중납량의 평균±표준편차는 3.70±1.35 ㎍/㎗이었으며, 남자와 여자는 각각 3.93±1.25 ㎍/㎗ 및 3.30±1.42 ㎍/㎗이었으나 양군 평균의 통계적 차이는 없었다. 음주, 흡연 및 BMI를 통제한 후 혈중납량을 종속변수로 한 중 회귀분석에서 연령은 양의 영향을 주는 변수로 나타났다. 여자대상자만을 대상으로 한 중 회귀분석에서 교란변수를 통제한 후 연령은 경골납량에 경계수준의 양의영향을 나타내었다. 결론: 40세 이상의 우리나라 중년성인의 경골납량의 평균±표준편차는 3.49±4.99 ㎍/g이었으며, 혈중납량의 평균±표준편차는 3.70±1.35 ㎍/㎗이었다. 혈중납량은 연령과 성과 유의한 양의 관련성이 있었으나, 골중납량은 여자에서만 연령과 경계수준의 유의한 관련을 나타냈다.
Objectives: In order to investigate the level and the association between bone lead and blood lead levels of non-occupationally, lead-exposed Koreans, the authors studied the lead biomarkers of 137 middle aged Koreans (86 males and 51 females) older than whose age were above 40 years. Methods: The tibia lead level was selected as the bone lead indicator of cortical bone, and the blood lead level was also measured. The tibia lead level was measured by K-shell XRF with 30-minute measurement of each subjects. The blood lead level was analyzed by AAS method. Results: The mean (SD) of the tibia lead level of the 137 study subjects was 3.49 (4.99) ㎍/g, and tended to be higher. The mean (SD) of tibia lead level in male subjects (was 3.90 (4.88) ㎍/g) and larger than in that of female subjects (2.80 (5.14) ㎍/g), but without no statistical significance was observed. The mean (SD) of blood lead level of all total subjects was 3.70 (1.35) ㎍/dl, and tended to be higher. The mean (SD) of blood lead level in male subjects (was 3.93 (1.25) ㎍/㎗) and larger than in that of female subjects (3.30 (1.42) ㎍/㎗), but without no statistical significance was observed. In multiple regression analysis of blood lead levels after adjusting for covariates, age was a significant independent variable. A weak association of age with tibia lead in female subjects was also observed in multiple regression analysis. Conclusion: The mean (SD) of tibia and blood lead levels of middle aged Koreans whose ages were over 40 years old were 3.49 (4.99) ㎍/g and 3.70 (1.35) ㎍/㎗, respectively. Age and sex were positive predictors of blood lead level in multiple regression analysis after controlling for the covariates. However, in multiple regression analysis whereas age was weakly association with tibia lead level only in female subjects in multiple regression analysis.
